5 Worst Resident Evil Boss Fights

Across the various installments within the Resident Evil series, there are numerous boss battles that players encounter. Regrettably, not all of these encounters offer enjoyable or memorable experiences, instead, they can range from moderately irritating to downright exasperating. These types of bosses may discourage you from replaying a game multiple times solely to skip the battle, or initiate a replay only to feel apprehension when approaching the boss area due to the impending confrontation.

This list includes some frustrating and even glitchy boss encounters, ranging from tedious to completely flawed. Although not all battles receive such harsh criticism, these particular ones are often subject to more complaints than other bosses. Despite the presence of many well-designed fights to balance them out, playing through a replay of an RE game remains challenging when you anticipate facing one of those dreaded battles.

1) Del Lago (Resident Evil 4)

Del Lago’s battle proves challenging, regardless of whether it’s encountered in the original Resident Evil 4 or its 2023 remake. As with many games that feature boss battles within watery environments, Del Lago stands out as a difficult encounter due to the necessity of adopting a patient approach – essentially waiting for the right moment to act.

In all iterations of Resident Evil 4, there’s no option to hasten this battle. Instead, you must endure, evade attacks, and capitalize on openings to strike Del Lago. While this isn’t the most frustrating aspect that could arise in a boss fight scenario, when you’re well-prepared for the encounter yet are compelled to prolong it due to its design, it can become quite irritating.

2) Simmons (Resident Evil 6)

It’s frustrating with Simmons because instead of having one definitive boss battle like William Birkin in RE2, his fights are spread out over multiple encounters. However, he falls short as an intriguing antagonist and the transformations between each fight seem illogical and lacking in impact.

Some of these boss variations, such as his flying version and T-rex version, were difficult to handle, while others were enjoyable to battle. Yet, the frequent reappearance of Simmons in various forms became repetitive, making combat tiresome despite the changing mechanics. A more diverse selection of bosses would have enhanced Leon’s campaign experience.

3) Ndesu (Resident Evil 5)

In Resident Evil 4, Ndesu resembles the El Gigante boss fight, except you combat him with vehicle-mounted firearms. In Resident Evil 5, however, Ndesu is a different giant who’s infested with Uroboros, resulting in bug-like creatures emerging from his body as vulnerable spots.

On harder settings, Ndesu can be quite challenging to overcome. Yet, even on easier difficulties, defeating him becomes frustrating due to the necessity to use weapons mounted on vehicles against him. This gives off a vibe reminiscent of a rail-shooter game, limiting your ability to adjust positions effectively. In essence, it feels like another battle with El Gigante, but this time with less excitement and flair.

4) Infected Bat (Resident Evil 0)

The Encounter with the Infected Bat could take you by surprise as the game subtly avoids signaling a boss battle is imminent. Awareness of its approach allows for strategic readiness, such as stockpiling ammunition for the grenade launcher. Lacking this forewarning may lead to considerable struggle, given the bat’s formidable difficulty in defeating without a grenade launcher.

In simpler terms, during the battle with the boss, running out of ammo for defeating the bat can result in a soft-lock situation where you’re unable to leave the room mid-fight to gather more ammo. Consequently, this forces you to reload an earlier save and repeat parts of the game, which can be quite annoying.

5) Heisenberg (Resident Evil Village)

In Resident Evil Village, Heisenberg’s section is notoriously challenging, making sense for his boss fight to be incredibly tough. Regrettably, the difficulty of Heisenberg’s battle is so high that it often leads players to become stuck. Even with a well-thought-out strategy, such as moving towards his right arm to dodge attacks from the left, defeating him remains a significant challenge. This level of difficulty is enough to drive some players away from the game altogether.

There’s plenty of enjoyment to be derived from the game Resident Evil, yet it’s important to note that not every aspect of the series is flawless or consistently enjoyable. A significant determinant of whether a section is fun or challenging often hinges on the design of its boss fight. Since you can only battle a boss for so long before needing a break from the game, these are battles that frequently necessitate such pauses.

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2025-08-16 21:25