Mayim Bialik Says GLP-1 Medication Gave Her “Explosive Diarrhea”

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Mayim Bialik is opening up about her experience with GLP-1s.

An actress from The Big Bang Theory shared her experience with unpleasant side effects after receiving weight loss injections.

Mayim Bialik shared in an essay for The Free Press, published June 5th and titled “My GLP-1 Nightmare,” that after being advised to try a low dose of a synthetic GLP-1 medication, she suffered unpleasant side effects. These included severe diarrhea, intensely foul-smelling burps that made her self-conscious, and sneezing fits whenever she attempted to eat or drink – a reaction she learned is called “snatiation.”

She described feeling intensely uncomfortable with painful cramps, a swollen stomach, and widespread body aches, like having the flu. She also couldn’t keep any fluids down, experiencing severe diarrhea so frequently that she didn’t always make it to the bathroom – this happened more than three times.

As Mayim put it, “To say I had an adverse reaction would be somewhat of an understatement.”

Concerned about side effects from the weight loss drug, the 50-year-old woman consulted a gastroenterologist. The doctor told her that her symptoms, though strong, weren’t uncommon.

She remembered him explaining that these drugs significantly impact the body and should only be used for severe obesity and related health problems. She didn’t believe her situation qualified as severe enough to warrant their use.

The doctor also thought that other medicines Mayim was taking could have played a role in how she was feeling.

Mayim, a mother to 18-year-old Miles and 15-year-old Frederick with her ex-husband Michael Stone, started taking a weight loss medication because a doctor suggested it could alleviate long-term health issues she’s faced since adulthood.

The actress from Blossom was diagnosed with Graves’ disease, a thyroid condition caused by the immune system, when she was 23 years old. She has said that she was given medication at the time, but didn’t change her diet or lifestyle, and now believes this may have gradually worsened her condition.

Mayim later found out she had several conditions, including connective tissue disease, mast cell activation syndrome (MCAS), Sjögren’s syndrome, and dysautonomia.

She said that over the past few months, three different doctors recommended she try a GLP-1 medication. They didn’t suggest it for weight loss, even though she’d gained about twenty pounds after menopause, but because research indicates these drugs may help lower inflammation throughout the body, which can be beneficial for autoimmune diseases.

Although a GLP-1 medication wasn’t the life-changing solution Mayim had anticipated, she emphasized that her personal experience doesn’t diminish the positive results others have achieved with it.

She stated that GLP-1 medications have been truly beneficial for those who really needed them, and she’s confident of that. However, she noted that there’s very little discussion about the potential negative side effects or problems that can occur.

For more stars who have detailed their experience with GLP-1s, read on…

Long before appearing on Dancing With the Stars, the star of Secret Lives of Mormon Wives shared that she was using semaglutide injections – sold as Ozempic and Wegovy – to help with weight loss.

She revealed on YouTube in January 2023 that she’s found something that helps her lose fat, explaining that it feels like her body simply eliminates it through urine. She admitted that’s her understanding of how it works.

The Queer Eye star revealed in October 2025 that they began using a GLP-1 medication after experiencing a health issue in 2023.

After experiencing a health scare, Jonathan decided to schedule a colonoscopy. If the results were normal, he planned to try a GLP-1 medication, as he simply wasn’t feeling well.

Okay, seriously, Jonathan said the most amazing thing! He was talking about how he’s been losing weight and getting into Solidcore, and he said his body has never looked this good. Like, ever! He’s always wanted abs – abs! – and he’s never had them before. And he’s so happy, he’s been taking his shirt off all the time, which… honestly? Good for him! I’m living for this transformation, it’s incredible!

Even after losing seventy pounds with medication, Jonathan continued to champion body positivity.

Honestly, I’m completely obsessed with the idea of body neutrality! It’s like, your body doesn’t have to look a certain way for you to be worthy of love or happiness. It doesn’t matter what your body looks like – you deserve to be celebrated and loved just as you are, period. It’s so freeing to think about it that way!

The comedian started taking the medication Mounjaro for Type 2 diabetes in late 2022. She revealed her significant weight loss in May 2025.

Rosie shared on Instagram, expressing her surprise at her transformation, along with the hashtags #mounjaro, #weightloss, and #bodydismorphia.

Meghan Trainor and her husband, Daryl Sabara, bonded even more after becoming parents to their son, Riley, in 2021. They took on the intense 75 Hard challenge together and succeeded, as Meghan shared on their podcast, Workin’ On It. Afterwards, they started hearing from friends and even doctors about the weight loss drugs Mounjaro and Ozempic.

Both Daryl and I chose the smallest effective dose of Mounjaro, and we’re combining it with exercise and healthy eating,” explained the singer behind “All About That Bass.” “We began this health journey together.”

Kendra Wilkinson, known from Girls Next Door, tried a weight loss injection, but only used it once. She announced on Instagram in April 2025 that she’d started the shots, then quickly added that she was stopping and getting rid of it.

She started using GLP-1 medications again in March 2026, explaining on Instagram that she was carefully planning how she would use them this time.

“For me, it wasn’t just about weight… it was about feeling better, having more energy, and actually trusting the process instead of rushing it,” she continued. “I wanted something that felt transparent, supportive, and realistic for my lifestyle.”

In March 2025, the host of the Golden Globes spoke out in support of Ozempic, encouraging people to feel comfortable discussing their use of the medication.

She enthusiastically shared on The Tonight Show Starring Jimmy Fallon that she fully supports anyone considering Ozempic, saying, ‘I have no judgment – do what makes you feel good!’

She explained that she wants to encourage open conversation about weight loss, because she believes there’s a lot of unnecessary shame surrounding it. She feels this shame actually comes from people who prefer she stay larger, and are upset by her progress. They may feel threatened by her confidence and personality as she transforms.

The model stated in December 2024 that she previously used Ozempic, but she quit using it when she began competing on Dancing With the Stars the prior autumn.

Nader admitted to trying the viral trend when it first started, saying, ‘Everyone was doing it.’ He explained it initially made him feel sick, but he actually enjoyed it. However, when he competed on Dancing with the Stars, he decided he couldn’t continue with it.

Brooks explained that the medication made her lose some of her desire and energy to exercise. She chose to focus on dancing instead, and stopped getting injections.

In November 2024, Dog the Bounty Hunter’s daughter revealed she’d lost 58 pounds over ten months by changing her diet and using the weight loss drug Tirzepatide. She said she now feels proud of her progress and how she looks.

Before discovering a treatment that suited her, she had a difficult experience with Ozempic. She told TopMob News, “I really disliked it. It made me feel nauseous whenever I tried to eat, and sometimes I couldn’t eat anything at all. My body just didn’t react well to it.”

The star of The Real Housewives of New York City recently addressed rumors about her noticeable transformation between seasons 14 and 15.

She explained to Us Weekly in October 2024 that it’s common for people on reality TV to face rumors about cosmetic procedures, like getting plastic surgery or using medications like Ozempic. She strongly dislikes Ozempic and said she would never inject herself with it.

Following online rumors that Lizzo had used the drug Ozempic for weight loss after she shared a photo of her slimmer physique, the singer responded with a video. The video featured a popular sound clip from the movie Django Unchained, spoken by Christoph Waltz’s character, who says, “It’s like a reward.”

Later, though, the musician admitted she gave some injectibles a shot. 

Lizzo explained to Trisha Paytas on the Just Trish podcast in June 2025 why she stopped taking GLP-1 medications sooner than expected. She said Ozempic works by helping you eat less, making you feel full. But, she added, if you can control your eating habits and willpower on your own, you can achieve the same results without the medication.

In a September 2024 episode of her podcast, Dream On, Kate Moss’s younger sister shared that starting Ozempic was “the worst decision I ever made.”

The model became sick after accidentally taking a dose of medication intended for someone weighing around 220 pounds or more, and had to be treated in the emergency room because they couldn’t keep any food or water down.

She explained that she became so severely dehydrated she had a seizure, which she described as the most frightening experience of her life. A friend had to hold her feet to keep her still, and she remembers her face and body becoming tightly clenched and tense during the ordeal.

In April 2024, Jon Gosselin, known from the show Jon & Kate Plus 8, told Page Six that he lost 32 pounds over two months using semaglutide injections – the generic version of the drug Ozempic.

“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”

Ree Drummond, known as the Pioneer Woman, clarified in a March 2024 blog post that she didn’t use Ozempic or any comparable drugs to lose 50 pounds in 2022.

I truly believe everyone’s path is their own, and you’ll never get a judgmental word from me about the choices people make in life. It’s all about finding what works for you, and I fully support that!

In August 2023, the actor, known for his role on 30 Rock, shared on Today With Hoda and Jenna that he lost weight using Ozempic, which reduced his appetite.

In March 2024, he revealed a surprising update about his health. Appearing on The Tonight Show Starring Jimmy Fallon, he joked, “I’ve actually managed to out-eat the effects of Ozempic,” and explained that he had gained 40 pounds.

He later told TopMob News he was just kidding about his previous statement, but added that Ozempic had actually been very helpful for him and he was happy he used it.

The star of The Real Housewives of Dubai revealed she used Ozempic after experiencing a midlife crisis at age 45.

As someone who’s navigated the changes that come with turning 40, I totally get how much harder it becomes to lose weight. I was getting asked all the time how I’d managed to stay in shape, and I wanted to be honest. I actually used Ozempic, and honestly, I think it’s a really effective tool if it’s something you and your doctor think is right for you. It’s been a game-changer for me, and I wanted to share that with everyone.

During a July 2024 appearance on Watch What Happens Live, the Real Housewives of New Jersey star stated she doesn’t use Ozempic. She then jokingly revealed she’s actually using Mounjaro, adding that she’s happy with her current weight and has plenty of energy.

I was so surprised to hear that one of the former stars of The Real Housewives of Atlanta shared her experience with a weight-loss injection – and that it unfortunately didn’t work for her. It’s brave of her to be so open about it, and I really feel for her. It just goes to show that these things aren’t always a quick fix, even with medical help.

She explained that a certain treatment didn’t reduce her hunger at all. While some people lose their appetite, she continued to eat appetizers, a full meal, and even dessert. She admitted feeling down when she saw it working for others but not for herself, leading her to question what was different about her and why she wasn’t experiencing the same results. She shared these feelings in June 2024.

I’m not a medical professional, but it’s clear there’s a lot of data on how effective different treatments are,” she said in an interview with Fox News Digital. “Ozempic can be really helpful for some, but it also carries potential risks.

Former Little Mix member Perrie Edwards, who has previously discussed her battle with anorexia, shared that it was challenging to ignore online comments about her weight and rumors she was using the drug Ozempic.

Jade shared with The Guardian in August 2025 that she struggles with the temptation to try Ozempic. While she understands why others use it, she worries it could be triggering for her, given her past struggles with eating disorders, and she’s unsure where it might lead.

The actress from Beverly Hills, 90210 reportedly used a weight loss drug after having her son, Beau, in 2017.

She mentioned on her podcast in April 2024 that Ozempic wasn’t effective for her, but Mounjaro helped her lose weight.

The actress explained to Francesca Amiker of TopMob News that it’s crucial to remember medications are prescribed for specific individuals and shouldn’t be used simply for cosmetic reasons.

Raven said, “Take care of business, but please prioritize the medicine for those who truly need it.”

In September 2023, the host of Talk U.K. shared that she lost 42 pounds after using the medication Ozempic earlier that year.

She told TopMob News that the decision is entirely personal. She also clarified that using aids to help with weight loss isn’t something to be ashamed of – it’s completely acceptable.

She added, “We don’t have to bulls–t.”

Sharon’s daughter has also weighed in on the Ozempic trend.

It’s fantastic!” the former Fashion Police star told TopMob News in January 2024. “There are so many ways to lose weight, so why not choose something more enjoyable than just exercising?”

 

Kate Winslet, known for her role in Titanic and previously scrutinized by the media for her weight, recently spoke about the current trend of focusing on weight loss.

In a March 2024 interview with The New York Times Magazine, Kate confessed she wasn’t familiar with Ozempic, saying, “All I know is that it’s some pill people are taking.”

“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”

In December 2023, the star of The Hills shared that she had recently lost 22 pounds without using Ozempic. She told Page Six that she believes there are no easy fixes when it comes to weight loss, and she wouldn’t personally use the drug, nor does she want to comment on others who are. She made it clear she wouldn’t name anyone or get involved in the discussion.

Heidi said she’s looking for something sustainable that also involves effort and hard work.

During her June 8, 2023 appearance on Watch What Happens Live, the Trainwreck star openly criticized celebrities for being dishonest about using Ozempic to lose weight.

She said everyone seems to be trying Ozempic, and people are being dishonest about it. Speaking to Andy Cohen, she called out those claiming they’re simply eating smaller portions, saying, ‘Stop lying. If you’ve lost weight, it’s either from Ozempic or cosmetic procedures.’

Senator Schumer, known for being upfront about her own health choices, explained, “It’s important to be honest with people. I openly shared that I had liposuction.”

She shared that she quickly became very interested in Ozempic in 2022, but ultimately stopped taking the medication, which is typically used for Type 2 diabetes. She explained it interfered with her ability to enjoy time with her son, Gene, making it unsustainable for her to continue.

I remember being too sick to play with my son,” Schumer said. “I was really thin at the time, and he was throwing a ball at me, but I just didn’t have the strength to play with him.

Dr. Drew recently told TopMob News that people have complicated reactions to shows like Special Forces: World’s Toughest Test. He explained that while viewers are drawn to the drama, they also tend to be critical of the participants.

He added that if a treatment could offer benefits, people should definitely consider trying it.

Forget winter, a hot take is coming.

The actress, known for her role in Game of Thrones, didn’t hold back when discussing Ozempic and the ads promoting it.

On April 5, 2023, the actress shared a post on her Instagram Story from writer Sophie Vershbow. Vershbow’s tweet criticized ads for Ozempic, a weight-loss drug, which she saw in the Times Square subway station, stating they were unwelcome. The ads featured slogans like “One shot to lose weight” and “A weekly shot to lose weight.”

Turner adding her own commentary, writing, “WTF.”

Novo Nordisk, the company that makes Ozempic, has stated that the drug is not currently approved by the FDA for long-term weight loss.

Novo Nordisk, the maker of Ozempic, acknowledges that some doctors are prescribing the drug for weight loss, even though it’s not officially approved for that purpose. The company states it doesn’t promote or encourage this practice and is committed to following all U.S. laws and regulations regarding how its products are marketed. Novo Nordisk also expresses confidence that doctors are carefully considering each patient’s specific health needs when choosing the appropriate medication.

Comedian Chelsea Handler is speaking out about her experience with Ozempic. She says her doctor prescribed the drug for anti-aging purposes without fully explaining what it was.

She explained on the January 25, 2023 episode of Call Her Daddy that she hadn’t realized she was using the product, and someone told her it could help her lose about five pounds.

But while she tried the drug, Handler noted that she didn’t like how it made her feel.

She remembered returning from vacation and immediately using the medication. A few days later, she met a friend for lunch who confessed to feeling sick because she was taking Ozempic. The woman realized she was also feeling nauseous, but she attributed it to jet lag from her trip to Spain.

Handler eventually quit taking the medication because she didn’t really need it anymore. She shared any leftover doses with friends.

She admitted to giving Ozempic to around four or five friends, explaining she decided against using it herself because she thought it was unnecessary. She described having friends come to her house to receive injections, scheduling appointments like ‘at 1 o’clock’ or ‘at 2 o’clock’.

Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic. 

Kardashian responded to criticism in a January 2023 post, saying people shouldn’t dismiss her dedication to fitness. She explained she works out five days a week, starting at 6 a.m., and asked people to stop making assumptions about her. She finished by noting that, despite the new year, some people remain unkind.

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2026-06-06 18:19