Amy Schumer Addresses Her Weight Loss Transformation

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Amy Schumer is feeling the support.

Amy Schumer expressed her thanks to her friends and fans after sharing a photo of her weight loss journey. The picture, taken during a night out in Las Vegas with friends Jillian Bell and Alex Saks, showed her looking great in a short, black Miu Miu dress and highlighted her weight loss.

“Loving the love,” Amy wrote in the comments of the Oct. 4 Instagram post. “My legs thank you!”

People online were quick to praise her fit legs, and Chelsea Handler even exclaimed, “Yes!!!!! Look at this pic!!!!”

Kathy Griffin playfully expressed her annoyance with Lee Daniels’ legs, saying she could hardly speak to him. Daniels responded with a teasing remark, calling him “Skinnnnnnnny mommmmma.”

Added Amy Sedaris, “You look incredible. Look at those pins!!!”

Amy has openly discussed her struggles with weight loss, including trying Ozempic, a medication for type 2 diabetes. While some celebrities use it for weight loss because it suppresses appetite, it unfortunately made Amy, 44, very sick and unable to get out of bed.

I recently opened up on *The Howard Stern Show* about a really tough time I went through. I was feeling incredibly sick – actually vomiting – and just generally wasting away. It was a scary experience, to be honest, and I wanted to be open about how unwell I was feeling.

 

Amy explained that while taking the medication, she felt too tired to play with her and her husband Chris Fisher’s six-year-old son, Gene.

“I’m in bed and my son’s like, ‘Can you play tag?’” she recalled. “And I’m like, ‘I can’t.’”

She’s happy for people who’ve benefited from Ozempic, but she strongly disapproves of anyone who isn’t honest about using it.

I was so relieved when she finally said what everyone’s thinking! She was on *Watch What Happens Live with Andy Cohen* last year and just called people out for pretending they’re losing weight through diet and exercise alone. She was like, ‘Seriously, enough with the ‘smaller portions’ excuse!’ She pointed out that a lot of people are probably using medications like Ozempic or have had cosmetic procedures, and she just wants everyone to be honest about it. It was so refreshing to hear!

She added, “Be real with the people. When I got lipo, I said I got lipo.”

For more stars speaking out about Ozempic, keep reading…

The comedian began taking the medication Mounjaro for Type 2 diabetes in late 2022. She publicly revealed her significant weight loss in May 2025.

Rosie shared on Instagram, expressing disbelief at her transformation, along with the hashtags #mounjaro, #weightloss, and #bodydismorphia.

Meghan Trainor and her husband, Daryl Sabara, bonded even further after welcoming their son, Riley, in 2021. They shared on their podcast, *Workin’ On It*, that they successfully completed the challenging 75 Hard program together. They also revealed that they started hearing from friends and even doctors about the weight loss drugs Mounjaro and Ozempic.

Both Daryl and the singer decided to start with the smallest effective dose of Monjaro, and they’re pairing it with regular exercise and healthy eating. “We do everything together,” the singer, known for “All About That Bass,” shared. “And that’s how we began this process.”

Kendra Wilkinson, known from the show *Girls Next Door*, tried a weight loss injection once. She announced it on Instagram in April 2025, saying she only had one dose before deciding to stop and throwing it away.

The model explained she didn’t want to take any chances with her health. As a mother of two, she’d heard alarming stories about people needing emergency room visits and even surgery, and she wanted to avoid that at all costs.

In March 2025, the host of the Golden Globes spoke out in support of Ozempic, encouraging people to feel comfortable discussing their use of the medication.

She enthusiastically shared on *The Tonight Show Starring Jimmy Fallon* that she fully supports anyone considering Ozempic. ‘I’m all for it,’ she said, adding, ‘I have no problem with anyone making that choice.’

Oh my gosh, she *gets* it! She totally said what I’ve been thinking forever! It’s like, people need to be able to talk about weight loss without feeling bad, because the only shame around it comes from
 well, honestly, it’s from people who *want* you to stay bigger. They’re just furious when you start to change, because they feel like that’s all they have to define themselves by! You’re suddenly becoming someone with energy and a personality, and it threatens them, you know? It’s so true! She explained it perfectly!

The model stated in December 2024 that she previously used Ozempic, but she quit taking it when she began competing on *Dancing With the Stars* the prior autumn.

Nader admitted to trying the viral trend when it first started, saying everyone else was doing it too. He explained it initially made him feel sick to his stomach, but he actually enjoyed it. However, when he competed on *Dancing with the Stars*, he realized he couldn’t continue doing both.

Brooks explained that the medication made her lose some of her drive and energy to exercise. She chose to focus on dancing instead, so she stopped taking the medication.

Dog the Bounty Hunter’s daughter revealed on November 1st that she’d lost 58 pounds over ten months by changing her diet and using the medication Tirzepatide. She shared that this journey has made her feel proud of her progress and confident when she looks in the mirror.

Before discovering a solution that suited her, she had a difficult experience with Ozempic. She told TopMob News, “I really didn’t like it. It made me feel nauseous, and sometimes I couldn’t eat anything at all. My body just didn’t react well to it.”

The star of *The Real Housewives of New York City* addressed rumors about her noticeable transformation between seasons 14 and 15.

It’s common for people on reality TV to face rumors about getting plastic surgery or using weight-loss drugs like Ozempic, she explained to *Us Weekly* in October 2024. She personally dislikes Ozempic and said she’d never inject herself with it.

Following speculation online that Lizzo may have used the drug Ozempic to lose weight, sparked by a recent photo showing her slimmer physique, the singer posted a video. The video featured a popular sound clip from the movie *Django Unchained*, spoken by Christoph Waltz’s character, who says, “It’s like a reward.”

In a September 2024 episode of her podcast, *Dream On*, Kate Moss’s sister shared that starting Ozempic was “the worst decision I ever made.”

Oh my gosh, I was so worried when I heard! Apparently, she accidentally took a dose meant for someone much bigger – like, over 220 pounds! It made her so sick she couldn’t even keep anything down, and she ended up needing to go to the emergency room. I was absolutely terrified for her!

She explained that she became so dehydrated she actually had a seizure, which she described as the most frightening experience of her life. A friend had to hold her feet to keep her still, and she remembers her face and body becoming completely stiff and tense. It was a truly terrifying situation.

In April 2024, Jon Gosselin, known from the show *Jon & Kate Plus 8*, told *Page Six* that he lost 32 pounds over two months by using semaglutide injections – the generic version of the drug Ozempic.

“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”

Ree Drummond, known as the Pioneer Woman, wrote on her blog in March 2024 that she didn’t use Ozempic or any similar drugs to lose 50 pounds in 2022.

She emphasized that she would never criticize anyone for making that life choice.

In August 2023, the actor best known for 30 Rock shared on Today With Hoda and Jenna that he lost weight using Ozempic, which reduced his appetite.

In March 2024, he revealed a surprising update about his health. Appearing on *The Tonight Show Starring Jimmy Fallon*, he joked, “I’ve actually managed to out-eat the effects of Ozempic,” and explained he’d gained 40 pounds.

He later told TopMob News he was just kidding, and explained, “Ozempic worked well for me, and I was happy to have used it.”

The star of *The Real Housewives of Dubai* revealed she used Ozempic while experiencing a midlife crisis at age 45.

Caroline Stanbury recently discussed the challenges of weight loss after turning 40 on her podcast, *Uncut & Uncensored*. She explained that many women have asked her how she’s managed to lose weight, and she was honest about using Ozempic, calling it a very effective tool for those who can access it.

During a July 2024 appearance on *Watch What Happens Live*, the *Real Housewives of New Jersey* star stated she doesn’t use Ozempic. She jokingly followed up by admitting she’s actually using Mounjaro, and happily shared that she loves her current weight and has plenty of energy.

A former cast member of *The Real Housewives of Atlanta* shared that she wasn’t successful in losing weight using the medication she tried.

She explained that a certain treatment didn’t reduce her appetite at all. Unlike some people who lost their desire to eat, she continued to enjoy appetizers, a full meal, and even dessert. She shared this in June 2024, adding that seeing others succeed with the treatment while it didn’t work for her left her feeling down and wondering what was wrong with her.

I’m not a medical expert, but I’ve seen a lot of information about what treatments are effective and what isn’t,” she said in an interview with Fox News Digital. “Ozempic seems to have both positive effects and potential risks.

Former Little Mix member Perrie Edwards, who has previously discussed her battle with anorexia, confessed it was challenging to ignore online rumors about her weight and speculation that she was using Ozempic.

In August 2025, Jade told The Guardian she constantly struggles with the temptation to try Ozempic. While she understands why others use it, she worries that, given her past struggles with eating disorders, taking the drug could be a dangerous path for her.

The actress from *Beverly Hills, 90210* reportedly used a drug to lose weight after having her son, Beau, in 2017.

She mentioned on her podcast in April 2024 that Ozempic wasn’t effective for her, but Mounjaro helped her lose weight.

As a long-time admirer of hers, I was really struck by what she said to Francesca Amiker at TopMob News. She made such a vital point – that medications are prescribed for specific needs, and it’s wrong to disregard that just to achieve a certain look. It’s something I truly believe in, and I was so glad she spoke up about it.

Raven said, “Take care of business, but please prioritize the medicine for those who truly need it.”

In September 2023, the host of *Talk U.K.* shared that she lost 42 pounds after using the medication Ozempic earlier that year.

Oh my gosh, she *said* it! She actually said it to TopMob News! It’s like she was speaking directly to me, honestly. She basically confirmed that if anyone’s using something to help with weight loss, it’s totally okay and *not* something to be ashamed of! It’s not a ‘dirty little secret’ at all, and she just… gets it! I’m telling you, she’s the best. It’s so empowering to hear her say it’s perfectly fine to do what you need to do for yourself!

She added, “We don’t have to bulls–t.”

Sharon’s daughter has also weighed in on the Ozempic trend.

“It’s fantastic,” the former star of *Fashion Police* said to TopMob News in January 2024. “There are so many ways to lose weight, so why not choose something more enjoyable than just exercising?”

 

Kate Winslet, known for her role in *Titanic* and previously scrutinized by the media for her weight, has spoken out about the current trend of focusing on weight loss.

In a March 2024 interview with *The New York Times Magazine*, Kate confessed she wasn’t familiar with Ozempic, saying, “I really don’t know what it is. All I’ve heard is that it’s a pill some people are using.”

“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”

I was so impressed when I read that my favorite, the star of *The Hills*, lost 22 pounds naturally at the end of 2023! She specifically said she didn’t use Ozempic, and honestly, I really admire that. She told *Page Six* that she believes there are no easy fixes in life, and she wouldn’t ever consider taking a shortcut like that. She didn’t want to call anyone out, but she made it clear it’s just not something she’d personally do, and I totally get it!

Heidi said she’s looking for something sustainable and doesn’t mind putting in the effort to make it work.

During her June 8, 2023 appearance on *Watch What Happens Live*, actress Amy Schumer criticized celebrities for being dishonest about using Ozempic for weight loss.

She said everyone is trying Ozempic, and people are being dishonest about it. Addressing Andy Cohen, she called out those claiming they’re simply eating smaller portions, saying, ‘Just stop—you’re either on Ozempic, or you’ve had cosmetic procedures.’

Senator Schumer, known for being honest about her health choices, explained, “Just be upfront with people. I openly admitted to having liposuction.”

She shared that she quickly became interested in Ozempic in 2022, but ultimately stopped taking the medication—intended for Type 2 diabetes—because it interfered with her time with her son, Gene.

I remember being too sick to play with my son,” Schumer shared. “I was really thin at the time, and he was throwing a ball at me, but I just didn’t have the strength to participate.

Dr. Drew recently told TopMob News that people have complicated reactions to shows like *Special Forces: World’s Toughest Test*. He explained that while viewers are often fascinated, they also tend to be critical of the participants.

He added that if a treatment could be beneficial, people should definitely consider trying it.

Forget winter, a hot take is coming.

The actress, known for her role in *Game of Thrones*, didn’t hesitate to voice her thoughts on Ozempic and the commercials promoting it.

On April 5, 2023, the actress shared a tweet on her Instagram Story from writer Sophie Vershbow. Vershbow’s tweet expressed strong disapproval of advertisements for Ozempic that were displayed in the Times Square subway station. The ads, which Vershbow included in her tweet, promoted weight loss with phrases like “One shot to lose weight” and “A weekly shot to lose weight.”

Turner adding her own commentary, writing, “WTF.”

Novo Nordisk, the company that makes Ozempic, has stated that the drug is not currently approved by the FDA for long-term weight loss.

Novo Nordisk, the maker of Ozempic, stated that while they’ve noticed some doctors are prescribing the drug for weight loss, they do not support or encourage using their medications for purposes other than those officially approved. The company emphasizes it follows all U.S. laws and regulations regarding how it promotes its products. Novo Nordisk also expressed confidence that doctors are carefully considering each patient’s specific health needs when choosing the best treatment.

Comedian Chelsea Handler is speaking out about her experience with Ozempic. She says her doctor prescribed the drug for anti-aging purposes without fully explaining what it was.

Okay, so I was *listening* to the latest Call Her Daddy, the one from January 25th, 2023, and she was talking about this thing! She said she hadn’t even realized she was *on* it, but someone told her if she ever wanted to lose just five pounds, this was the way to go. Seriously, I’ve been researching it ever since! It’s like, if *she* says it’s good, it *has* to be good, you know?

But while she tried the drug, Handler noted that she didn’t like how it made her feel.

She remembered returning from vacation and immediately using the medication. A few days later, while having lunch with a friend, her friend mentioned feeling sick and revealed she was taking Ozempic. She realized she was feeling unwell too, but initially attributed it to jet lag from her trip to Spain.

Handler eventually stopped taking the medication because she didn’t need it for her health. She shared any leftover doses with friends.

She admitted to giving Ozempic to around four or five friends, explaining she decided against using it herself because she thought it was unnecessary. She described having friends come to her house to receive injections, scheduling appointments throughout the afternoon.

Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic. 

Kardashian responded to criticism in a January 2023 post, pointing out her dedication to fitness. She explained she works out five days a week, starting at 6 a.m., and asked people to stop making assumptions about her. She ended by noting that even at the start of a new year, some people remain unkind.

Besides using weight-loss medication, Dr. Dubrow shared in January 2023 that he briefly took Mounjaro himself to understand its effects on the body.

The star of *Botched* said she was really impressed with the weight loss medication. She didn’t need to lose a significant amount of weight herself, but she was curious to experience it firsthand, since many of her patients used it. She wanted to see how it felt to take the medication when you’re not diabetic and only need to lose a small amount – around 10 to 15 pounds.

Dr. Dubrow didn’t share the details of his weight loss or how long he used the medication, but he did say he’s stopped taking it now.

He decided to stop taking the medication because he wanted to regain his appetite, and he’d also been feeling mildly nauseous.

As a lifestyle expert, I’ve seen firsthand how sensitive people are about changes in appearance. Recently, there’s been a lot of talk about my weight loss, and honestly, it’s been a little overwhelming. Some people started speculating that I was using medication to help, and I wanted to address that directly. It’s tough when assumptions are made about your health, and I felt it was important to be open and honest with my followers about what’s been going on.

Responding to a comment on an Instagram post from January 5, 2023, Richards firmly denied using Ozempic, stating, “I am NOT on ozempic.” She further clarified, “Never have been.”

The reality star debunked the rumors again, confirming in an Instagram post from *Page Six* on January 16, 2023, that she is not taking the medication. This wasn’t the first time she’d addressed these claims.

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2025-10-07 04:49