Serena Williams & More Who’ve Served Their Takes on Weight-Loss Drugs

Serena Williams is sporting a new look.

The tennis star recently shared she lost 31 pounds and opened up about her experience.

During a recent episode of Today (August 21), Serena shared that many people have been inquiring about her latest health and fitness endeavors, which involve GLP-1s. She felt it necessary to publicly disclose this information.

Primarily, the Grand Slam champion aimed to reduce the social stigma surrounding medications like Ozempic, Mounjaro, Wegovy, Rybelsus, and other injectable treatments.

She elaborated, “To me, it was more about eliminating the perception of, ‘Is it an easy option? Is it a quick fix? Why bother with it?’

As a passionate admirer, I find myself often reflecting on Serena’s journey. She openly confessed that after welcoming her daughters Olympia, age 7, and Adira, age 2, with her partner Alexis Ohanian, she encountered challenges in maintaining her previous weight.

The athlete, who retired from professional tennis in 2022, shared that they were dedicating approximately five hours daily to their training. They also mentioned a consistent effort to reach a specific level on the scale, and emphasized that this point was never dipped below during their playing days.

Although she initially expressed reluctance, she eventually viewed GLP-1 medication as a challenge rather than an option. She admitted, “At first, when GLP-1s were introduced, I thought, ‘Not for me, absolutely not.’ But then I began to see it as an opponent, saying, ‘I can’t beat this opponent no matter what I do.’

Following experiments with various workout routines and adjustments to her eating habits, Serena found that GLP-1 medication seemed suitable for her. She obtained this medication through Ro, a healthcare firm where she is a compensated endorser and her spouse is an investor.

However, she pointed out that the decision wasn’t primarily influenced by how the drug affected her appearance, but rather by its impact on her emotions.

In a conversation with People, Serena expressed that she’s never experienced the need to conform to a specific physical image. She has always felt at ease regardless of her weight, be it more or less. However, she admitted that her body didn’t thrive at that particular weight. She suffered from joint pain and discomfort in various parts of her body due to the extra weight, which she wasn’t accustomed to carrying since giving birth to her children.

She noted, “Although there was no issue with my previous size, it wasn’t what I desired. I simply craved to be in a place where I could comfortably feel myself.

Besides Serena, many other famous individuals have expressed opinions about weight-loss medications. For further insights into this topic from additional celebrities, continue reading ahead.

Since the end of 2022, the comedian has been taking medication for preventing Type 2 diabetes called Mounjaro. In May 2025, she presented a significant reduction in weight that was quite remarkable.

Rosie expressed disbelief, posting on Instagram, ‘#mounjaro #weightloss #strugglingwithselfimage.’

As a dedicated follower, I’ve learned that the saying goes: The couple who accomplishes challenges together, grows stronger together. After welcoming our eldest son Riley in 2021, my partner Daryl Sabara and I tackled the 75 Hard challenge, and let me tell you, we truly excelled! This was something we shared during the April 9 episode of our podcast, Workin’ On It. Later on, we found out more and more of our friends, and even some of our doctors, were using Mounjaro and Ozempic for their own personal growth.

Daryl and the “All About That Bass” singer decided to begin their journey together, by each choosing the minimum dosage of Monjaro. They combined this with regular exercise and balanced meals. As Daryl put it, “we’re in this together,” and that’s exactly what they did.

Kendra Wilkinson, once a star on “The Girls Next Door,” tried out a single dose of an unnamed weight-loss injection back in April 2025. As she shared on her Instagram Stories, she stated, “I began using weight loss injections. I only took one though. Not for me. Tossing it away!

Eventually, the Playboy model made it clear that she was not keen on getting involved with any potential health hazards. “I’ve heard plenty of frightening tales,” she added, explaining her stance as a mother of two. “Hospital visits and surgeries are not appealing to me.

In March 2025, the host of the Golden Globes passionately advocated for open discussions about Ozempic, asserting its usage and encouraging a more accepting approach towards the medication.

She expressed her enthusiasm by saying on The Tonight Show Starring Jimmy Fallon, ‘Go for it!’ She doesn’t hold back her approval. If someone chooses to use Ozempic, she encourages them with an emphatic ‘Absolutely!’

She expressed, “I aim to encourage open conversations about it, as I believe there’s an unnecessary sense of embarrassment surrounding the topic. The embarrassment primarily stems from those who are thin and resent your weight loss. They’re enraged because they feel threatened by your new slenderness, as it diminishes their only perceived advantage – being thin themselves. However, you possess a vibrant personality that surpasses physical appearances.

Back in December 2024, the model mentioned that she briefly used Ozempic, but discontinued it when she joined ‘Dancing With the Stars’ the preceding autumn.

In an interview with Us Weekly, Nader admitted that he tried a small amount of it initially when everyone else was doing so. However, it made him feel extremely sick. Despite this, he enjoyed it and found himself unable to participate in both during his time on Dancing with the Stars.

As a die-hard admirer, let me express it this way: Brooks confessed that her willpower to exercise waned slightly due to the medication she was taking. In her own words, “It boiled down to a choice between working out and dancing, and I chose the latter. The weights took a backseat.

Dog’s Daughter Revealed on November 1 that she had shed 58 pounds over a 10-month period due to dietary changes and the utilization of Tirzepatide. She further mentioned her newfound ability to admire herself in the mirror, feeling incredibly proud of her weight loss progress.

Before discovering a suitable option, she encountered difficulties with Ozempic. In her interview with TopMob News, she expressed her dislike towards it: “I really didn’t like it,” she said. “I felt nauseous every time I ate. At times, I couldn’t eat at all because my body rejected it.

As a diehard fan, I couldn’t help but notice the striking transformation of The Real Housewives of New York City’s star from season 14 to 15. Yet, in a recent Q&A session, she squashed all speculation about her stunning makeover, assuring us it was merely the magic of good lighting and makeup!

In an interview with Us Weekly in October 2024, she expressed that when you’re involved in reality TV, it feels instinctive to comment on things like “She got plastic surgery,” or “She’s taking this medication,” or “She’s using Ozempic.” However, she made it clear that she strongly dislikes Ozempic and would never consider using it due to her aversion to self-injections.

Following rumors on social media that Lizzo might have been using Ozempic for weight loss, after she posted a picture showing a more slender physique, the Grammy winner responded with a video that played a popular TikTok sound clip featuring Christoph Waltz’s character from “Django Unchained” saying, “It feels like a reward.

In a September 2024 episode of her “Dream On” podcast, it was Kate Moss’s sister who disclosed the reason behind finding taking Ozempic as the “most regrettable decision I’ve ever made.

Following consumption of a dose typically intended for individuals weighing approximately 220 pounds and above, the individual encountered difficulty retaining solid foods or liquids, leading to an emergency room visit.

She confessed that she experienced a seizure due to severe dehydration, which turned out to be the most terrifying incident in her life. Her friend had to grip her feet as she went through it. The entire episode was incredibly frightening, with her facial muscles clenching and her body tensing up.

In a conversation with Page Six in April 2024, a former star of Jon & Kate Plus 8 revealed that he managed to shed an impressive 32 pounds over a span of just two months by administering semaglutide injections, which is the generic version of Ozempic.

“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”

In March 2024, the star of “The Pioneer Woman” publicly revealed on her blog that she had lost 50 pounds in 2022 without relying on Ozempic or comparable medications.

She said, “However, I won’t pass any judgment in a moment’s notice about those who opt for that path.

In August 2023, the former star of “30 Rock” explained during an interview on “Today With Hoda and Jenna” that he shed pounds by using Ozempic, as it helps reduce hunger.

In March of 2024, his health story took an unexpected twist. On The Tonight Show Starring Jimmy Fallon, he jokingly shared, “I’ve mastered the art of eating more than Ozempic allows, resulting in a 40-pound weight gain.

Towards the end of that month, he made it clear to TopMob News that his previous statement was a joke. He expressed, “Ozempic worked wonderfully for me, and I was happy to take advantage of it.

In an open conversation, the cast member from “The Real Housewives of Dubai” discussed her decision to take Ozempic, following a period of self-reflection and change she experienced at age 45, which some people might refer to as a midlife crisis.

During her podcast on May 22, Caroline Stanbury shared that after turning 40, losing weight becomes particularly challenging. However, she’s encountered numerous women of the same age asking her how she managed it. She admittedly used Ozempic, a tool she believes is very effective for those who can utilize it.

During a July 2024 interview on Watch What Happens Live, the star of The Real Housewives of New Jersey clarified that she isn’t using Ozempic, but instead opted for Mounjaro. She then jokingly apologized and expressed her enthusiasm about maintaining this weight, saying “I love it! I have so much energy, if you couldn’t tell.

The former cast member of “The Real Housewives of Atlanta” confessed about her unsuccessful effort to shed pounds using an injection-based treatment for weight loss.

She revealed in June 2024 that the diet didn’t suppress her hunger at all. Instead of experiencing a decrease in appetite as some people do and saying ‘I can’t eat,’ she found herself enjoying appetizers, a main course, and dessert. It seemed to have no effect on her eating habits. She admitted that when a diet works for others but not for her, it leaves her feeling down, questioning ‘Why isn’t this working for me?’ or ‘What makes me different from others who see results?’

As a devoted enthusiast, I can’t delve into the medical aspects, but let me tell you this: there’s an abundance of insights out there on what’s effective and what isn’t. From my perspective, Ozempic carries some remarkable advantages, yet it also holds certain risks that should be taken seriously.

Previously a member of the band Little Mix, who’s publicly shared experiences battling anorexia, confessed it was tough to steer clear of Ozempic amidst widespread web conjecture concerning her weight.

In an interview with The Guardian in August 2025, Jade shared that she constantly struggles to resist using Ozempic. She clarified that she doesn’t pass judgment on others who do use it, but given her past struggles with eating disorders, she worries about the potential consequences of taking such a substance for herself.

In 2017, following the birth of her son Beau, the character from Beverly Hills, 90210 opted for a weight-loss strategy involving drugs.

In the April 2024 episode of her podcast named “misSPELLING”, she disclosed that Ozempic didn’t help her, but Mounjaro did. She went on to say that she shed some pounds while using Mounjaro.

The actress emphasized to Francesca Amiker at TopMob News that it’s crucial to comprehend that specific medications are designed for specific individuals, and not misuse them merely for fashionable reasons.

Carry on, but remember to keep those life-saving meds for those truly in need. I’m rooting for you!”

Or, more fanatically:

“Press ahead, but never forget who truly needs that precious medicine. A fellow devotee cheering you on every step of the way!

In September 2023, the host of Talk U.K. shared that she lost approximately 42 pounds by taking Ozempic during the early part of the year.

She shared with TopMob News that the decision is entirely yours to make. And if you’ve resorted to something to aid in weight loss, it’s nothing to be ashamed of because it’s completely acceptable.

She added, “We don’t have to bulls–t.”

Sharon’s daughter has also weighed in on the Ozempic trend.

As an ardent enthusiast, I can’t help but exclaim my awe! In an interview with TopMob News back in January 2024, I shared my thoughts, stating, “I absolutely adore it!” The question at hand: losing weight. But

 

The actress who played the lead role in the movie “Titanic,” previously a subject of gossip magazines concerning her weight, expressed her thoughts on current weight loss trends.

In a conversation with The New York Times Magazine, Kate openly acknowledged her lack of knowledge about Ozempic. She explained that while she has heard of it being a medication, her understanding is limited to it being a pill that individuals are consuming.

“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”

In December 2023, the actress from Hills disclosed that she had shed approximately 22 pounds without utilizing Ozempic. She expressed her views on other celebrities using this drug during an interview with Page Six, stating, “Life doesn’t offer shortcuts. If someone is taking a shortcut, I can’t comment on it.” She refrained from naming names and preferred not to delve into the matter, noting that such practices are not something she would ever engage in.

Heidi mentioned she was looking for something that is both sustainable and requires effort or dedication.

During her June 8, 2023 episode of Watch What Happens Live, the actress known for Trainwreck didn’t mince words when she publicly criticized other celebrities for not openly admitting their use of Ozempic as a weight loss aid.

She stated to Andy Cohen, “Everybody seems to be eager to give it a try, even people’s mothers. It’s been quite deceptive when people say, ‘Oh, I’m eating smaller portions,’ she commented sarcastically. Essentially, she was saying, ‘Enough already! You’re either using Ozempic or similar treatments, or you’ve had cosmetic work done. Just be honest about it.’

Openly discussing her previous medical treatments, Schumer candidly stated, “Speak honestly with others. Just as I openly admitted to getting liposuction, I told everyone that I had indeed undergone the procedure.

In 2022, she openly declared that she developed an immediate interest in Ozempic. However, she clarified that due to its negative impact on her capacity to spend time with her son named Gene, it was not feasible for her to continue using the drug intended for Type 2 diabetes management.

Schumer remembered feeling unwell and unable to join in playtime with her son due to illness. She was extremely thin, and even simple activities like catching a ball were challenging for her.

Dr. Drew shared with TopMob News at Fox’s Special Forces: World’s Toughest Test season two event in Los Angeles on Sept 12, 2023, that there is a diverse response towards interventions such as these. He explained that while people are intrigued by it, they simultaneously hold a peculiar sense of apprehension or criticism.

Speaking as a lifestyle expert, I’d say, “When a useful remedy is available, I always advocate for individuals to reflect on it.

Forget winter, a hot take is coming.

The former star of “Game of Thrones” had no reservations when expressing her thoughts on Ozempic and its commercials.

On the 5th of April, 2023, an Instagram Story was shared by the actress, who reposted a tweet from author Sophie Vershbow. The tweet read, “I’d rather those Ozempic ads covering Times Square subway stations just disappear entirely.” Among the photos Vershbow posted were ads displaying phrases like, “Just one shot to lose weight,” and another with a similar message, “A weekly injection to lose weight.

Turner adding her own commentary, writing, “WTF.”

Previously, Novo Nordisk informed us at TopMob News that Ozempic isn’t currently authorized by the FDA for long-term weight control.

Although we understand that some medical professionals might be prescribing Ozempic to aid in weight loss, Novo Nordisk does not advocate or endorse the use of our drugs for unapproved purposes. We strictly adhere to all relevant U.S. laws and regulations regarding the promotion of our products. It is our belief that healthcare providers are assessing each patient’s unique circumstances and making informed decisions about which medication best suits their individual needs.

Comedian Handler found that Ozempic wasn’t a joke when she discovered her doctor, who specializes in anti-aging, had prescribed it to her unknowingly.

She mentioned during the January 25, 2023 episode of Call Her Daddy that she didn’t realize she was on it, and then added: ‘If you’re looking to lose around 5 pounds, this might be helpful.’

But while she tried the drug, Handler noted that she didn’t like how it made her feel.

After returning from my vacation, I resumed using it. A few days later, I met up with a friend for lunch, and she mentioned, “I’m not actually eating anything. I feel so sick, I’m taking Ozempic.” This made me feel a bit queasy as well. However, I had recently returned from Spain and was still experiencing jet lag.

In the end, Handler chose to discontinue the medication as it wasn’t essential for her health. Furthermore, she donated the leftover doses to her friends.

“She stated that she gave approximately four to five of her friends Ozempic, as she felt it was unnecessary for herself. Since the medication is intended for heavier individuals, she would invite people over and say something like, ‘I’ll see you at 1, I’ll see you at 2.'”

Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic. 

In a January 2023 post, Kardashian said, “Don’t underestimate my years of exercise routine. Five days a week, I wake up at 6 am for workouts. Let’s put an end to the assumptions. Seems like even in a new year, there are still rude people.

Besides disclosing that he had briefly taken the weight-loss medication, Mounjaro, Dubrow also shared in January 2023 what effects it might have on the body.

The star of Botched enthusiastically expressed, “I found it absolutely fantastic! I didn’t need to lose a significant amount of weight, but out of curiosity and since many of my patients were on it, I decided to give it a try. After all, I was not diabetic and only had 10 to 15 pounds to shed.

Dr. Dubrow refrained from sharing the specific amount of weight he lost or the duration he used the medication, but he did confirm that he is now no longer taking it.

He shared that his decision to stop the medication stemmed from a desire to rekindle his hunger again. Additionally, he mentioned that he was experiencing a mild form of nausea.

The actress from The Real Housewives of Beverly Hills openly discussed speculations that she was using a particular medication, following observations of her weight loss by her social media followers.

Richard replied under an Instagram post from January 5, 2023 featuring himself with his friends after a workout, stating, “I’m definitely not taking Ozempic.” In another comment, he clarified further, “I’ve never used it.

In a January 16, 2023 post on Instagram, as reported by Page Six, the Bravo star refuted the rumors, making it clear that she is “absolutely NOT using” the medication.

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2025-08-24 13:18