Margaret Cho Says She Had an Accident Onstage Due to Weight Loss Drug

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Margaret Cho will never forget this messy performance.  

The comedian recently revealed that early in her career, a weight loss drug she was taking caused her to have an embarrassing accident while performing on stage.

On the January 7th episode of the How to Fail podcast, Margaret, 57, explained that she began experimenting with various drugs. She also described consuming foods designed to rapidly move through the digestive system, such as Olean – chemically produced fats used for frying, and artificial sweeteners – which caused constant diarrhea.

Olean, a brand of chips and snacks made with a fat substitute called Olestra, became well-known for causing digestive problems and was eventually taken off shelves in the mid-2000s. Margaret explained that she began eating only these snacks while also taking medication to block fat absorption. This combination unexpectedly became a problem when she wore a white outfit during a stand-up performance.

She described a terrifying moment near the end of her performance when she unexpectedly began experiencing a bowel movement she couldn’t control. She explained it wasn’t solid waste, but a large amount of oily substance – she compared the appearance to grease from pepperoni pizza – that began leaking from her rectum while she was still on stage.

The former Drop Dead Diva star explained that she received a standing ovation and an encore request, but she had to quickly exit the stage by hiding behind the curtains.

Let me tell you, that incident with Margaret didn’t end when it seemed! She actually continued to struggle with some digestive issues right there backstage. She really needed to feel completely comfortable before she could finally leave, poor thing.

She explained that she initially reacted by crying and feeling disgusted. She was worried about getting orange stains on her car seat, but also found the situation strangely funny. After that experience, she stopped taking those drugs, though she continued to explore other ways to lose weight.

Margaret shared that she’d dealt with insecurities about her body since she was a child, something she briefly addressed in her first TV show, All-American Girl. While she’s still proud of creating the series, which aired from 1994 to 1995, she explained that critics paid more attention to her weight than to the stories she was trying to tell.

She said she’d always been overweight and had come to terms with it. As a comedian, she assumed her weight wouldn’t be an issue, believing you could be any size and still be funny. However, she was surprised to find that it actually did matter, and she felt pressured to lose a significant amount of weight.

Margaret struggled with diet pills for years, and eventually, her focus on weight loss began to interfere with her work. She sought therapy, which, along with a 12-step program, proved very helpful in her recovery.

Keep reading to see more stars who have detailed their use of weight loss drugs… 

Long before appearing on Dancing With the Stars, the star of Secret Lives of Mormon Wives shared that she was using semaglutide injections – sold as Ozempic and Wegovy – to help with weight loss.

She revealed on YouTube in January 2023 that she’s using something she calls a ‘secret sauce’ to lose fat, and believes it’s simply eliminated through urination.

In October 2025, the star of Queer Eye revealed they began using a GLP-1 medication after experiencing a health issue in 2023.

After experiencing a health scare, Jonathan decided he would get a colonoscopy. If the results were clear, he planned to try a GLP-1 medication, as he simply wasn’t feeling well.

Jonathan shared that he’s in the best shape of his life after losing weight and starting Pilates at Solidcore. He said he’s always wanted visible abdominal muscles, and now he finally has them. He feels great and has been showing off his physique by taking his shirt off more often.

Even after losing 70 pounds with medication, Jonathan continued to champion body positivity.

As a lifestyle expert, I’m a huge advocate for body neutrality. Honestly, what you look like has absolutely nothing to do with your value as a person. Your worth isn’t tied to your appearance, and you deserve love and celebration exactly as you are, no matter your body type. It’s about recognizing your inherent worth, period.

The comedian began taking Mounjaro, a medication for Type 2 diabetes, in late 2022. By May 2025, she had lost a significant amount of weight and publicly displayed her transformation.

Rosie shared on Instagram, expressing disbelief at her transformation, along with the hashtags #mounjaro, #weightloss, and #bodydismorphia.

Meghan Trainor and her husband, Daryl Sabara, bonded even further after welcoming their son, Riley, in 2021. They took on the intense 75 Hard challenge and successfully completed it, as Meghan shared on their podcast, Workin’ On It. Afterwards, they started hearing from friends and even doctors who were using medications like Mounjaro and Ozempic.

Both Daryl and I chose the smallest effective dose of Mounjaro, and we’re combining it with exercise and healthy eating,” explained the singer behind “All About That Bass.” “We began this health journey together.”

Okay, so I tried one of those weight loss injections, you know, the ones everyone’s talking about? I really did! But honestly, after just one shot, I decided it wasn’t for me. I posted about it on Instagram, and I’m just tossing the rest – it’s not my thing!

The model said she decided it wasn’t worth risking her health. She’d heard about too many people getting seriously sick and needing emergency room visits or even surgery, and she wanted to avoid that at all costs, especially as a mother of two.

In March 2025, the host of the Golden Globes spoke out in support of Ozempic, encouraging people to feel comfortable discussing their use of the medication.

She enthusiastically shared on The Tonight Show Starring Jimmy Fallon that she fully supports anyone considering Ozempic, saying, ‘I’m like, ‘Do it!’ I have no problem with it – if you want to try it, go for it!’

She explained that she wants to create a more open conversation about weight loss, as she believes there’s a lot of unnecessary shame surrounding it. She feels this shame mostly comes from people who prefer she remain larger, and are upset by her progress. They may feel threatened by her confidence and personality as she changes.

Okay, so she finally admitted it! Back in December 2024, she confessed she used to take Ozempic, but she stopped right before she started on Dancing With the Stars last fall. I mean, can you believe it? Still, I’m so proud of her for pushing through on the show!

Nader admitted to trying the popular trend when it first started, like a lot of people. He said it made him feel sick to his stomach, but he actually enjoyed it. However, when he was competing on Dancing with the Stars, he realized he couldn’t continue doing both.

Brooks explained that the medication made her lose some of her desire and energy to exercise. She chose to focus on dancing instead, and stopped taking the medication altogether.

In November 2024, Dog the Bounty Hunter’s daughter revealed she’d lost 58 pounds over ten months by changing her diet and using the weight loss drug Tirzepatide. She said she now feels proud of her progress and happy with how she looks.

Before discovering a solution that suited her, she had a difficult experience with Ozempic. “I really didn’t like it,” she told TopMob News. “It made me feel sick to my stomach, and sometimes I couldn’t eat anything at all. My body just didn’t react well to it.”

The star of The Real Housewives of New York City addressed rumors about her noticeable transformation between seasons 14 and 15.

She explained to Us Weekly in October 2024 that it’s common for people on reality TV to face rumors about plastic surgery or weight loss drugs like Ozempic. She strongly dislikes Ozempic and said she would never inject herself with it.

Following online rumors that Lizzo used the drug Ozempic to lose weight, sparked by a recent photo showing her slimmer physique, the singer shared a video. The video featured a popular sound clip from the movie Django Unchained – a line spoken by Christoph Waltz’s character saying, “It’s like a reward.”

Later, though, the musician admitted she gave some injectibles a shot. 

Lizzo explained to Trisha Paytas on the Just Trish podcast in June 2025 why she stopped taking GLP-1 medications sooner than expected. She said that medications like Ozempic work by helping people eat less, making them feel full. However, she believes you can achieve the same results simply by controlling your eating habits and willpower.

Oh my god, you guys, I was listening to Lottie Moss’s podcast, ‘Dream On,’ last month, and she was SO brave talking about this! She basically said getting on Ozempic was the biggest mistake of her life – can you believe it?! I’m just obsessed with her honesty and how real she is, and I feel like everyone needs to hear this. It’s just…wow.

The model became sick after accidentally taking a dose of medication intended for someone much larger – around 220 pounds or heavier – and had to be hospitalized.

She explained that she became so severely dehydrated she had a seizure, which she described as the most frightening experience of her life. A friend had to hold her feet to keep her still, and she recalled her face and body becoming tightly clenched and tense during the ordeal.

In April 2024, Jon Gosselin, known from the show Jon & Kate Plus 8, told Page Six he lost 32 pounds in two months using semaglutide injections – the generic version of the drug Ozempic.

“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”

Ree Drummond, known as the Pioneer Woman, revealed in a March 2024 blog post that she didn’t use Ozempic or any comparable drugs to lose 50 pounds in 2022.

She emphasized that she would never criticize anyone for making that life choice.

In August 2023, the actor best known for 30 Rock revealed on Today With Hoda and Jenna that he lost weight using Ozempic, which reduced his appetite.

In March 2024, he revealed a surprising update about his health. Appearing on The Tonight Show Starring Jimmy Fallon, he joked, “I’ve actually managed to eat more than Ozempic allows!” and explained he’d gained 40 pounds.

He later told TopMob News he was just kidding, and explained, “Ozempic really helped me, and I’m happy I used it.”

The star of The Real Housewives of Dubai recently revealed she used Ozempic after experiencing a midlife crisis at age 45.

Caroline Stanbury admitted on her podcast, Uncut & Uncensored, that it’s incredibly difficult to lose weight after turning 40. She explained that many women have asked her how she’s managed to stay in shape, and she was honest about using the medication Ozempic, which she believes is a very effective weight loss tool for those who can access it.

During a July 2024 appearance on Watch What Happens Live, the Real Housewives of New Jersey star stated she doesn’t use Ozempic. She then jokingly revealed she’s actually using Mounjaro, adding that she’s happy with her current weight and has plenty of energy.

A former star of The Real Housewives of Atlanta shared that she wasn’t successful in losing weight using the weight-loss injection.

She explained that a certain treatment didn’t reduce her appetite at all. Unlike some people who lost their desire to eat, she continued to enjoy appetizers, a full meal, and even dessert. She shared this in June 2024, adding that seeing it work for others while it didn’t help her left her feeling down and wondering what was wrong with her.

While I’m not a medical professional, I’m aware of a lot of research on what treatments are effective and what isn’t,” she said in an interview with Fox News Digital. “Ozempic can be very helpful, but it also carries some risks.

Former Little Mix member Perrie Edwards, who has previously discussed her battle with anorexia, shared that it was challenging to ignore online comments about her weight and speculation that she was using the drug Ozempic.

In an August 2025 interview with The Guardian, Jade shared her struggle with the temptation to use Ozempic. While she understands why others choose to use it, she worries that, given her past with eating disorders, it could be a dangerous path for her personally.

Oh my god, I just found out that Shannen Doherty actually tried a weight loss drug after having her son, Beau, back in 2017! I mean, can you believe it? She was trying to get back in shape, and apparently, she turned to something like that. It’s just…wow. I’m so fascinated by everything she does, and this is just another layer to it all!

She mentioned on her podcast in April 2024 that Ozempic wasn’t effective for her, but Mounjaro helped her lose weight.

The actress explained to Francesca Amiker of TopMob News that it’s crucial to remember medications are prescribed for specific individuals and shouldn’t be used simply for cosmetic reasons.

Raven said, “Take care of business, but please prioritize the medicine for those who truly need it.”

Okay, so I was completely shocked when I found out that the host of Talk U.K. lost 42 pounds! Apparently, she started using Ozempic earlier this year, and the results are just… incredible. I’ve been following her journey, and I’m so impressed!

She told TopMob News that the decision is entirely personal. She also clarified that using aids to help with weight loss is common and shouldn’t be considered shameful.

She added, “We don’t have to bulls–t.”

Sharon’s daughter has also weighed in on the Ozempic trend.

“It’s fantastic,” the former Fashion Police star told TopMob News in January 2024. “There are so many ways to lose weight, so why not choose something more enjoyable than just exercising?”

 

Kate Winslet, known for her role in Titanic and previously scrutinized by the tabloids for her weight, recently spoke about the current focus on weight loss.

In a March 2024 interview with The New York Times Magazine, Kate admitted she wasn’t familiar with Ozempic, saying, “All I know is that it’s some pill people are taking.”

“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”

In December 2023, the star of The Hills shared that she had recently lost 22 pounds naturally, without using the weight loss drug Ozempic. She told Page Six that she believes in earning results and wouldn’t consider using shortcuts like that, and she doesn’t want to call out any other celebrities who might be. She made it clear it’s simply something she would never do.

Heidi said she’s looking for something sustainable and isn’t afraid of hard work.

During her June 8, 2023 appearance on Watch What Happens Live, the Trainwreck star openly criticized celebrities for being dishonest about using Ozempic to lose weight.

She said it seems like everyone is trying Ozempic, and people are being dishonest about it. Addressing Andy Cohen, she called out those claiming they’re simply eating smaller portions, saying they’re likely using Ozempic or have had cosmetic procedures and should be honest about it.

Senator Schumer, known for being honest about her health choices, explained, “Just be upfront with people. When I had liposuction, I openly admitted it.”

She shared that she quickly became interested in Ozempic in 2022, but ultimately stopped taking the medication, which is typically used for Type 2 diabetes. She explained that it interfered with her ability to enjoy time with her son, Gene, making it unsustainable for her to continue.

I remember being too sick to play with my son,” Schumer said. “I was really thin at the time, and he was throwing a ball at me, but I just didn’t have the energy to participate.

Dr. Drew recently told TopMob News that people have complicated reactions to shows like Special Forces: World’s Toughest Test. He explained that while viewers are often fascinated, they also tend to be critical of the participants.

He added that if a treatment could potentially help, people should definitely consider trying it.

Forget winter, a hot take is coming.

The actress, known for her role in Game of Thrones, didn’t hesitate to publicly share her thoughts on Ozempic and the commercials promoting it.

On April 5, 2023, the actress shared a tweet on her Instagram Story from writer Sophie Vershbow. The tweet criticized ads for Ozempic, a weight loss drug, that Vershbow saw in the Times Square subway station, calling them unacceptable. Vershbow’s tweet included photos of the ads, which highlighted the drug’s use for weight loss with phrases like “One shot to lose weight” and “A weekly shot to lose weight.”

Turner adding her own commentary, writing, “WTF.”

Novo Nordisk, the company that makes Ozempic, has stated that the drug is not currently approved by the FDA for long-term weight loss.

Novo Nordisk, the maker of Ozempic, acknowledges that some doctors are prescribing the drug for weight loss, even though it’s not officially approved for that purpose. However, the company states it does not promote or encourage this practice and is committed to following all U.S. laws and regulations regarding how its products are marketed. Novo Nordisk believes doctors are making informed decisions about the best medications for each of their patients.

Comedian Chelsea Handler is speaking out about her experience with Ozempic. She says her doctor prescribed the medication for anti-aging purposes without fully explaining what it was.

She mentioned on the January 25, 2023 episode of Call Her Daddy that she hadn’t realized she was trying to lose weight. Someone had told her, ‘If you want to lose five pounds, this will help,’ she explained.

But while she tried the drug, Handler noted that she didn’t like how it made her feel.

She remembered returning from vacation and immediately using the medication. A few days later, while having lunch with a friend, the friend mentioned feeling nauseous and that she was taking Ozempic. The woman realized she was feeling unwell too, but initially attributed it to jet lag from her trip to Spain.

Handler eventually stopped taking the medication because she didn’t need it for medical reasons, and she shared her leftover supply with friends.

She admitted to giving Ozempic to around four or five friends, explaining she decided against using it herself because she thought it was unnecessary. She described having friends come to her house to receive injections, scheduling appointments like ‘one at one, one at two’.

Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic. 

Kardashian defended her fitness routine in a January 2023 post, explaining that she works out five days a week, starting at 6 a.m. She asked people to stop making assumptions about her and expressed disappointment that negativity persists even at the start of a new year.

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2026-01-09 18:49