
The following contains spoilers for Resident Evil Requiem.
Resident Evil Requiem takes the series in a new direction, especially with the introduction of the Elpis antiviral and how it could impact future storylines. The game’s focus on Grace—initially believed to be Alyssa’s daughter—reveals a surprising backstory that unexpectedly links her to a core villain from the Resident Evil universe.
Grace’s unexpected role is setting up a major change for the Resident Evil series. While characters like Gideon and Zeno believe she holds the key to a dangerous weapon, she’s actually vital to creating a cure for the long-standing problems within the game’s world. This could dramatically reshape the future of the series, potentially taking it in a bold and exciting new direction.
Grace’s True Origins In Resident Evil Requiem, Explained

In Resident Evil Requiem, a major plot twist reveals that Grace Ashcroft isn’t the biological daughter of the journalist she was raised with. Instead, she was originally found as a young girl in Raccoon City by Oswell Spencer, the founder of the Umbrella Corporation and the mastermind behind the series’ conflicts. Spencer took a liking to her and, wanting to protect her from groups like the Connections who sought to weaponize his research, he secretly gave her to Alyssa to be raised. He also entrusted Alyssa with crucial information about the Connection.
Grace’s influence on Spencer, combined with his own pride, motivated him to create Elpis – a way to fix the problems his bioweapons had caused. If the player activates Elpis, they’ll find it’s more than just a weapon; it’s an anti-viral substance that neutralizes bioweapons and engineered viruses. This weakens powerful individuals like Zeno and cures deadly outbreaks, including the one affecting Leon. Gideon thinks Elpis was a final, malicious act, but Grace believes Spencer genuinely changed his mind and wanted to make amends. Regardless of his motives, Elpis has the potential to drastically alter the world of Resident Evil, considering how central bioweapons are to the series’ story.
How Elpis Could Change Resident Evil’s Future

During his final showdown with Zeno in Resident Evil Requiem, Gideon explains that Elpis has the potential to neutralize all biological weapons used throughout the series – weapons that have been used to create monsters, enhance people, and spread disease. This means Elpis could effectively counter many of the dangers and threats seen in Resident Evil. Considering how many creatures and characters have been created or empowered by these biological agents, the widespread use of Elpis could drastically change the future for groups like the Connection.
Future installments in the series could explore new threats within this world. The DLC for Resident Evil Village showed that Rosemary Winters’ powers from the Mold could last for years, suggesting ongoing dangers. The organization known as The Connection might try different strategies for taking over the world, pushing the heroes to adapt. Games could also deal with the consequences of the Elpis spreading and disrupting medicine, which could create even more problems.
Spencer’s involvement in creating the substance is intriguing, and it brings up the possibility of him seeking redemption – a theme not often explored in the Resident Evil series. While his actions might have been fueled by ego, it also appears he wanted to build a better world, despite his past contributions to the one filled with biological weapons and monsters. Future Resident Evil games could explore the consequences of these events, showing how Elpis impacts the world. This major development in Resident Evil Requiem could significantly change the series, and Capcom’s next game will likely need to address the ramifications of Grace’s connection to Spencer and how it alters the world’s current state.
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2026-02-28 20:14