Serena Williams Lost 31 Pounds Using GLP-1 Medication

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Serena Williams is serving up an honest look into her weight loss. 

The renowned tennis player, mother of Alexis (age 6) and Adira (age 2) with husband Alexis Ohanian, recently disclosed that a medication called GLP-1 was instrumental in her weight loss journey, helping her shed an impressive 31 pounds.

Serena, at 43, shared with Today on August 21 that she had been intermittently taking her medication but is now consistently using it. She expressed that this was a significant choice she made for her wellbeing, having experimented with various options beforehand.

Following the arrival of their child Alexis, both Serena and her husband found it challenging to maintain a healthy weight, as she revealed post her retirement in 2022.

She pondered, reflecting on the various life phases women experience. Regardless of what she tried – regular running, prolonged walking (often for hours, as advised), even engaging in professional sports-level physical activity – she found it difficult to regain the optimal health level she desired.

It appears that switching to a vegetarian and eventually a vegan diet did not seem to bring any noticeable benefits for her.

Following the arrival of Adira in 2023, Serena found that her struggles with maintaining a healthy body only intensified. In her own words, she expressed, “I realized it was time for a change: ‘I need to give this new approach a shot.’

Since starting to use a GLP-1 medication, Serena has not only noticed a substantial weight loss but also reported an overall improvement in her health.

In simpler terms, Serena mentioned that she’s experienced many challenges with her knees. She pointed out that although her pregnancies may have worsened the issue, it likely impacted potential victories she might have achieved during her professional career.

Despite holding 23 Grand Slam titles throughout her career, Serena acknowledges her use of GLP-1, aiming to erase the stigma surrounding it as a quick route for weight loss.

Having amassed 23 Grand Slam titles during her career, Serena openly admits her utilization of GLP-1 in an attempt to challenge and remove any negative connotations associated with this drug being considered a “shortcut” for weight loss.

Reflecting on her experiences as an athlete and having tackled numerous challenges, she found it difficult to achieve a healthy weight. Rest assured, she’s not one to resort to quick fixes or shortcuts.

Keep reading for more stars who have sounded off on weight loss medication… 

Since the end of 2022, the comedian has been taking the medication for managing Type 2 diabetes called Mounjaro. In May 2025, she unveiled her significant weight loss to the public.

Rosie expressed disbelief by posting on her Instagram: ‘#mounjaro #weightloss #transformedbody” (implied body dysmorphia)

After welcoming their firstborn son Riley in 2021, singer Meghan Trainor and her actor husband Daryl Sabara completed the 75 Hard challenge, as Meghan shared during the April 9 episode of their podcast Workin’ On It. “We really aced it,” she said. Later, they learned that more and more of their friends, as well as their doctors, were using Mounjaro and Ozempic.

Daryl and I decided to follow the same treatment plan for Monjaro, which involved taking the minimum dose, incorporating physical activity, and maintaining a balanced diet. As the popular ‘All About That Bass’ singer put it, “We do everything together.” She added that this shared journey was where we started.

Previously known star from “Girls Next Door,” Kendra Wilkinson, tried out a single dose of an unnamed weight loss injection. To be clear, it was just a single shot she administered. “I’ve started using weight loss injections,” she wrote on her Instagram Stories in April 2025. “Tried only one. Nope. Disposing of it!

In the end, the Playboy model stated that she had no intention of involving herself in any possible health hazards. “I’ve heard too many frightening tales,” she continued, “and as a mother of two, I’ve witnessed people ending up in the emergency room and even having surgeries. Not for me.

As a lifestyle expert, I wholeheartedly advocated for the open discussion of Ozempic usage during my tenure as the host of the Golden Globes in March 2025. I encouraged everyone to embrace transparency when it comes to this important medication, fostering an environment where people feel comfortable discussing its benefits and challenges.

She expressed her enthusiasm by saying, “I’m all for it!”, during an appearance on The Tonight Show Starring Jimmy Fallon. “I don’t judge. If you’re considering Ozempic, go ahead and try it, absolutely!

She expressed, “I wish to encourage more open discussions about it, as I believe there’s an unwarranted sense of embarrassment.” Pausing, she added, “This discomfort often stems not from individuals who are underweight, but rather from those who want you to remain overweight. It’s a form of jealousy, stemming from the fact that they feel threatened by your weight loss, since their perceived control or influence over you seems to be waning, as you possess dynamic qualities and a charming personality.

In December 2024, the individual mentioned that she had temporarily used Ozempic at some point in the past, but discontinued it when she began participating on Dancing With the Stars the preceding fall.

Nader shared with Us Weekly that initially, he tried a small amount of the trendy thing, and everyone seemed to be joining in. However, it made him feel quite queasy. Despite this, he admitted he found it appealing, and during his time on Dancing with the Stars, he discovered he couldn’t handle both simultaneously.

Brooks mentioned that while on the medication, her enthusiasm and energy for exercising slightly dwindled. She shared that it came down to a choice between working out and dancing, and ultimately decided to prioritize dancing, setting aside her workouts for the time being.

Dog’s daughter posted on November 1st that she managed to shed 58 pounds over a period of 10 months. This was achieved by altering her diet and utilizing the weight loss drug Tirzepatide. She expressed her satisfaction, stating, “I can now gaze at my reflection in the mirror and feel immensely proud of the progress I’ve made.

Prior to discovering a suitable option, she encountered difficulties with Ozempic. In an interview with TopMob News, she candidly shared her dislike for it, explaining that eating made her feel queasy and there were times when she couldn’t eat at all due to her body’s reaction.

The actress from “The Real Housewives of New York City” dismissed rumors suggesting a transformation occurred between seasons 14 and 15.

She shared with Us Weekly in October 2024 that it’s quite common when you’re part of reality TV to casually comment things like “She got plastic surgery,” or “She’s taking this medication.” However, she made it clear that she strongly dislikes Ozempic and would never consider using it herself because she’s against self-injections.

Following rumors on social media suggesting that Lizzo might have been using Ozempic for weight loss, after she posted a picture displaying a more slender figure, the Grammy winner responded with a video, featuring a famous quote from Christoph Waltz’s character in “Django Unchained”: “It’s like a reward.

In a September 2024 episode of her podcast, titled “Dream On,” Kate Moss’ sister shared the reasons she deemed taking Ozempic as “the biggest mistake I ever made.

Following consumption of a dose intended for individuals weighing approximately 220 pounds or higher, the individual experienced difficulty retaining any food or liquids, ultimately resulting in an emergency room visit.

She confessed, “I experienced a seizure due to extreme dehydration, which turned out to be the most terrifying incident I’ve faced in my life. My friend had to restrain my feet because it was so alarming. The entire situation was overwhelming; my facial muscles were clenching and my body was tensed up.

In an interview with Page Six in April 2024, a former star of Jon & Kate Plus 8 revealed that he shed 32 pounds over just two months by using semaglutide injections, which is the generic version of Ozempic.

“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”

In March 2024, the star of “The Pioneer Woman” revealed on her blog that she hadn’t lost 50 pounds in 2022 through the use of Ozempic or any comparable medications.

She stated, “Rest assured, there will be no criticism from me regarding those who opt for that path.

By August 2023, the former star of “30 Rock” revealed on “Today With Hoda and Jenna” that his weight loss was due to Ozempic, a medication that curbed his hunger.

In March 2024, it seemed like his health story took an unexpected twist. During an appearance on The Tonight Show Starring Jimmy Fallon, he shared, “I’ve mastered out-eating Ozempic”. As a result, he added 40 pounds to his weight.

Towards the end of the same month, he made it clear to TopMob News that his earlier statement was a joke. He also shared that Ozempic had been beneficial for him, expressing his gratitude for using it.

One of the stars from “The Real Housewives of Dubai” discussed her decision to use Ozempic, following a period of self-reflection or personal growth that she experienced around age 45, often associated with midlife crises.

During her podcast episode on May 22, Caroline Stanbury shared that losing weight after turning 40 can be extremely challenging. However, she has encountered numerous women in their forties who are amazed by her success and ask for her secrets. To be honest with everyone, she revealed that she utilizes Ozempic, a tool she believes is very effective if it’s something you can incorporate into your lifestyle.

During a July 2024 appearance on Watch What Happens Live, the star of The Real Housewives of New Jersey clarified that she is not using Ozempic, but instead, she admitted to being on Mounjaro. She playfully apologized for any confusion and expressed her delight in maintaining this weight, stating that she has an abundance of energy, which is evident if you observe closely.

The former star of “The Real Housewives of Atlanta” shared her unsuccessful effort to shed pounds using an injectable weight-loss treatment.

She stated in June 2024: “The diet didn’t help suppress my hunger; quite the contrary! In fact, I found myself indulging in appetizers, a full meal, and dessert. It had no effect on me whatsoever.

When others seem to benefit from it and I don’t, it can be disheartening. It might even make you think, ‘What’s wrong with me? Why isn’t this working for me?’

During her conversation with Fox News Digital, she mentioned that while she can’t provide medical insights, she does have knowledge about what’s effective and ineffective regarding a certain topic. She expressed her belief that Ozempic offers significant advantages, but also carries potential risks.

Previously a member of Little Mix, now openly discussing her battles with anorexia, confessed that resisting the use of Ozempic was challenging in the face of internet rumors regarding her weight.

Jade admitted to The Guardian in August 2025 that she constantly wrestles with the urge to use Ozempic. She doesn’t pass judgment on those who do, but given her past struggles with eating disorders, she expresses concerns about the potential consequences of using such a medication for herself.

As a lifestyle expert, I might rephrase it like this: After welcoming my son Beau in 2017, I, much like the character from Beverly Hills, 90210, turned to weight loss methods for a healthier post-pregnancy body.

In a podcast episode from April 2024, she expressed that Ozempic wasn’t effective for her. Instead, she switched to Mounjaro and it helped her shed pounds.

The actress emphasized during her interview with Francesca Amiker at TopMob News that certain medications are designed specifically for particular individuals, and they should not be disregarded merely to achieve a glamorous appearance.

Raven went on, “Carry on as necessary, but remember to reserve the medicine for those truly in need.

As a wellness advocate, I am thrilled to share my personal journey of weight loss. Last September, I found myself 42 pounds lighter, a transformation that began earlier in the year with the help of Ozempic. This incredible journey has not only improved my physical health but also boosted my confidence and overall lifestyle.

She shared with TopMob News that whatever decision you make is entirely your choice. And if you’ve resorted to something to aid in weight loss, it’s nothing to be ashamed of because it’s completely acceptable.

She added, “We don’t have to bulls–t.”

Sharon’s daughter has also weighed in on the Ozempic trend.

The former Fashion Police member expressed her enthusiasm to TopMob News in January 2024, saying, “I find it incredible! There are countless methods for shedding pounds, so why not opt for something more engaging than traditional exercise?

 

As an unabashed devotee, I’d like to share that the radiant star from the legendary Titanic, who at one point was a tabloid fixture over her weight issues, has voiced her opinions on the current weight loss craze.

In a conversation with The New York Times Magazine, Kate openly confessed her lack of knowledge about Ozempic in March 2024. She explained that the only thing she’s aware of is it being a pill that individuals are using or something similar to that.

“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”

The actress known as The Hills confided in Page Six in December 2023 that she had shed a significant 22 pounds without relying on Ozempic. When asked about other celebrities utilizing the drug, she expressed her stance, “Life doesn’t offer shortcuts. If someone is resorting to those shortcuts, I can’t comment.” She refrained from naming names and emphasized that such a practice wasn’t something she would engage in.

In my opinion, I’m on the hunt for solutions that are both long-lasting and eco-friendly. However, I also value efforts that don’t necessitate an overly burdensome amount of work.

During her interview on Watch What Happens Live on June 8, 2023, the actress from Trainwreck didn’t mince words when she publicly criticized other celebrities for not being truthful about their use of Ozempic as a weight loss aid.

It seems everyone, even their family members, are considering giving it a try. She expressed this to Andy Cohen, who has often shared his thoughts on the popular Ozempic trend. Essentially, she said, ‘Enough with the false modesty about smaller portions.’ She implied that if someone is promoting smaller portions, they’re likely using Ozempic or similar medications, or have undergone cosmetic procedures. Her message was clear: if you are, just be honest about it.

Openly discussing her prior health interventions, Schumer candidly stated, “Always be truthful with others. When I underwent liposuction, I openly admitted that I did.

In 2022, she confessed to developing an instant interest in Ozempic, yet clarified that due to its negative impact on her ability to spend time with her son Gene, it was not a sustainable option for her to continue using the Type 2 diabetes medication.

Schumer remembered feeling extremely unwell and unable to play with her son, as she was so thin that even playing catch with him proved challenging.

Dr. Drew shared with TopMob News at Fox’s Special Forces: World’s Toughest Test season two event in Los Angeles on Sept. 12, 2023, that there is a combination of curiosity and apprehension regarding such interventions. He noted that people are attracted to it, yet they also harbor a certain skepticism or appraisal.

He added, “Given a potentially beneficial medicine, certainly, we should motivate individuals to consider it.

Forget winter, a hot take is coming.

The former actress from “Game of Thrones” didn’t hesitate to express her views on Ozempic and its commercials.

On April 5, 2023, an Instagram post by the actress shared a tweet from writer Sophie Vershbow expressing displeasure with Ozempic advertisements covering the subway station in Times Square. The tweet read something like, “Enough with the Ozempic ads taking over Times Square!” The ads featured phrases such as “One easy shot for weight loss” and “Lose weight weekly with this single shot,” which seemed to bother Vershbow.

Turner adding her own commentary, writing, “WTF.”

Previously, the pharmaceutical company Novo Nordisk informed TopMob News that Ozempic hasn’t been endorsed by the U.S. Food and Drug Administration (FDA) for long-term weight management purposes.

Though it’s known that certain medical professionals might be recommending Ozempic for weight loss purposes, Novo Nordisk does not endorse, suggest, or encourage the use of our medications beyond their approved uses. We strictly adhere to all U.S. laws and regulations when marketing our products, as stated in a company declaration. In making treatment decisions, we trust that healthcare providers are considering each patient’s unique circumstances and choosing the appropriate medication accordingly.

Comedian Handler didn’t find Ozempic as a joke – unaware that her ‘anti-aging physician’ had prescribed the medication to her, not fully understanding its nature.

During the January 25, 2023 episode of Call Her Daddy, she expressed that she wasn’t aware she was on it. She then mentioned, “If you’re looking to lose five pounds, this can be helpful.

But while she tried the drug, Handler noted that she didn’t like how it made her feel.

After returning from my vacation, I administered the medication to myself. A few days later, over lunch with a friend, she mentioned that she wasn’t eating much due to feeling extremely nauseous as she was on Ozempic. I also confessed to feeling queasy, but attributed it to jet lag following my recent trip to Spain.

Eventually, Handler decided to stop taking the drug as it was not medically required for her. Furthermore, she generously distributed the leftover doses among her friends.

She mentioned that she gave Ozempic to approximately four or five of her friends, realizing it was unnecessary as it was intended for heavier individuals. Instead of using it herself, she finds herself offering appointments to visitors, saying “Come over at 1, come over at 2.” This way, she has people coming to her house instead of taking the medication herself.

Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic. 

In a January 2023 post, Kardashian wrote, “Let’s give credit where it’s due – my dedication to working out for years is no joke. Five days a week, I wake up at 6am to exercise. Let’s put an end to the assumptions. It seems even the new year hasn’t slowed down the rude comments.

Apart from disclosing his temporary usage of the weight-loss drug Mounjaro back in January 2023, Dubrow shared insights on how the medication impacts the human body.

The Botched star expressed that they found it remarkable. They didn’t need to shed a significant amount of weight, but they were curious since many of their patients were on it and wanted to experience the effects firsthand, as they weren’t diabetic and only had 10-15 pounds to lose.

As a devoted admirer, I couldn’t help but follow Dr. Dubrow’s health journey closely. Despite him not revealing the exact pounds shed or the duration of his medication use, one thing is clear – he’s now off that medication for good!

He shared his reasoning for stopping the medication, stating, “I felt like maybe it was time to rekindle my appetite again,” while mentioning that he also endured a mild feeling of queasiness.

A cast member from “The Real Housewives of Beverly Hills” addressed rumors that she was using medication due to her weight loss, which her social media followers had pointed out.

As a devoted fan, I want to clarify that in response to a post from January 5th, 2023 on Instagram featuring Richard’s photo with her friends after a workout, she made it clear that she is not using Ozempic. In another interaction, she further emphasized that she has never taken Ozempic.

As a lifestyle enthusiast, I’d like to clarify a point regarding a popular figure, often associated with Bravo. Contrary to recent speculations, she has made it clear in her January 16th, 2023 Instagram post via Page Six, that she is not currently on any medication as rumors might suggest. She’s putting an end to these rumors, emphasizing that she is not taking the medication in question.

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2025-08-21 18:19